Physics-Driven Platform

The Silicon Therapeutics physics-driven drug design platform combines quantum physics, statistical thermodynamics, molecular simulations, a dedicated HPC super-computing cluster, purpose-built software, in-house laboratory and clinical development capabilities. We have developed the most accurate force field in the industry to model both proteins and small molecules and are continuously developing new tools and applications to improve drug design.

Quantum Mechanics

Quantum mechanics is the most accurate way to simulate the behavior of molecules and interactions between molecules and allows us to predict with remarkable accuracy the complex biomolecular interactions critical to biological systems. We believe deploying quantum physics methods to tackle the challenges in protein targets previously thought to be “undruggable” will yield the most accurate predictions and facilitate our mission to deliver new medicines to patients.

Quantum Mechanics

Thermodynamics

At Silicon Therapeutics, we use statistical thermodynamics to compute biologically relevant quantities such as binding affinity, selectivity, allostery, membrane permeability and solubility from molecular dynamics simulations. The decomposition of energies into components and functional groups leads to insights that could not otherwise be gained. This process allows our scientists to reach a deeper understanding of protein targets and design new ligands that modulate properties in desirable ways.

Thermodynamics

Molecular Simulation

We simulate biological molecules using the laws of physics. This approach allows us to predict interactions, energies and the conformational behavior of our drug discovery targets. We go beyond binding, simulating the dynamic behavior of protein-ligand interactions to reveal how conformational changes drive biological activity and how that activity can be modulated with small molecules.

Molecular Simulation

Supercomputing Infrastructure

We have built the Silicon Therapeutics high-performance computing environment to meet the company’s requirement for state-of-the-art computing power. We believe our dedicated, built-for-purpose, super-computing cluster provides more computing resources per project than any other biotechnology or pharmaceutical company.

Supercomputing Infrastructure