Scientific Paradigm

Silicon Therapeutics is a fully integrated drug discovery and development company working to drug the most challenging protein targets in medicine.

Our multi-disciplinary team is advancing a paradigm shift in medicine by pioneering a physics-driven approach to drug design. Our drug design platform is purpose-built to design novel small molecule therapeutics capable of addressing biologically and genetically validated but previously intractable protein targets. Our lead program is a highly differentiated small molecule STING agonist anticipated to enter the clinic in late 2020.

We base our drug development process on a proprietary physics-driven platform comprised of our expertise in quantum mechanics, statistical thermodynamics, molecular simulations and super-computing infrastructure.

Physics-Driven Platform

Our physics-driven drug design platform combines quantum physics, statistical thermodynamics, molecular simulations, a dedicated HPC super-computing cluster, purpose-built software, in-house laboratory and clinical development capabilities. We have developed the most accurate force field in the industry to model both proteins and small molecules and are continuously developing new tools and applications to improve drug design.

Physics-Driven Platform

Drug Design

We’re focused on biologically and genetically validated protein targets that have, until now, been considered “undruggable.” Our drug design process is built on three essential concepts: our multi-disciplinary team; integrated approach and deep physics insights; and our leadership in understanding conformational modulation.

Drug Design

Scientific Publications

Members of our senior science team are the lead authors for some of the most innovative and frequently cited publications appearing in prestigious industry journals, with over 200 peer-reviewed articles and over 20,000 citations.

Scientific Publications