Company

Silicon Therapeutics (“SITX”) is a privately-held, physics-driven integrated drug discovery company in the preclinical IND stage targeting innate immunity to start, but with the capability to move into many other franchise opportunities. The Company’s initial pipeline is focused on modulation of the innate immune system to “light the spark” within immunologically cold tumors by using its physics-enabled drug discovery engine for the design of small molecule therapeutics and the lead program is in late stage preclinical studies. SITX’s discovery efforts as well as physics-based platform are all completely in-house, with a full wet lab as well as a team of over 25 experienced R&D professionals spanning biology, biochemistry, chemistry, biophysics (NMR + X-ray) & preclinical sciences. SITX’s engine leverages quantum mechanics and molecular dynamics, which are deployed on its own internal super computer composed of over 400 GPU’s and FPGA’s and allows SITX to accurately simulate the physical motion and properties of biological targets at an atomistic level resolution. The platform is completely proprietary to SITX and was built from the ground up with the purpose of addressing difficult targets and using simulations to break through bottlenecks that has plagued traditional drug discovery approaches on such targets. It is currently the ONLY company which owns the entire spectrum of physics-driven drug discovery from chip-to-clinic with a team of over 40 individuals in Boston.

The Company’s initial focus in on innate immunity and its pipeline is currently composed of one project entering into IND-enabling studies, another one entering hit-to-lead and two more ramping up. It’s unique advantage in designing small molecules using all atom simulations has allowed it to advance a systemically available small molecule STING agonist into a preclinical development. The program is ramping up for IND enabling studies entry to the clinic in 2020. This differentiated product can be administered systemically via an IV dose and has single agent effects in early mouse efficacy studies using PD1 resistant tumor models and is a “rule-of-5” compliant small molecule. Beyond this one program, the Company is also advancing an ADAR inhibitor which can be considered an innate immune check-point as well as a multitude of targets that explore Innate Immunity’s role in cancer biology.

Job Summary

Silicon Therapeutics is seeking an enthusiastic, motivated and capable individual with expertise in surface plasmon resonance (SPR) and experience in one or more of the following techniques: saturation transfer difference NMR (STD NMR), isothermal titration calorimetry (ITC), differential scanning fluorimetry (DSF), microscale thermophoresis (MST).  Core responsibilities include SPR assay development, medium-throughput compound screening, fragment screening and routine testing of compounds in SPR assays. Additional responsibilities could include testing of small molecules in STD NMR, ITC, DSF or MST.  This is an exciting role for a scientist who is looking to contribute to the discovery and development of cancer therapies. The successful candidate will work as part of a collaborative team of scientists with expertise in protein production and biophysics supporting hit-ID, hit-to-lead, and lead-ID phases of our innate immuno-oncology drug discovery programs and will have the opportunity to mentor more junior scientists.

Job Responsibilities

  • Core responsibilities: design and develop surface plasmon resonance (SPR) assays for compound screening, fragment screening and routine small molecule testing.
  • Additional responsibilities could include testing of small molecules in STD NMR, ITC, DSF or MST.
  • In collaboration with group members, design protein constructs for use in biophysical assays.
  • Work as part of a cross-functional project team to provide high-impact results.
  • Carefully document research workflows, data and protocols using an electronic laboratory notebook.
  • Capture experimental results in database.
  • Organize and present data to group members and project team members.
  • Mentor more junior scientists in the group.

Required Skills & Qualifications

  • Ph.D. with 4-8 years of industry experience with a degree in biophysics, biochemistry or related discipline.
  • Expertise in SPR assay design and development and testing of small molecules in SPR.
  • Hands-on experience in one or more of the following techniques: saturation transfer difference NMR (STD NMR), isothermal titration calorimetry (ITC), differential scanning fluorimetry (DSF), microscale thermophoresis (MST).
  • Proficient in relevant programs for data analysis and visualization.
  • Demonstrated ability to work independently to troubleshoot and optimize experiments.
  • Demonstrated ability to mentor others.
  • Excellent communication skills.
  • Experience using Sierra Sensors/Bruker SPR systems a plus.

 

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