Associate Director, Molecular Physics

Location: New York, NY

Silicon Therapeutics, a drug discovery company headquartered in Boston is looking for an experienced chemical physicist/physical chemist to join our computational platform team. Working closely with other platform team members, the candidate will lead and expand a team to develop and implement computational models in molecular physics to enable computation-driven drug discovery. Competitive pay, equity, strong perks, and a fun working environment, along with the opportunity to do cutting edge science to design better medicines, are all good reasons to join us! 

Responsibilities: 

Assemble and lead a team to develop and implement models and methods in computational molecular physics, including but not limited to

Develop accurate and computationally efficient models of molecular interactions, including quantum chemistry, force field, and machine-learning models, for small molecules, proteins, and nucleic acids

Develop multiscale simulation methods that combine force field, quantum chemistry, and machine learning models to enable highly accurate molecular simulations, including binding free energy predictions and protein conformational ensemble predictions 

Leverage existing biophysical data and collaborate with experimental groups to design experiments and obtain new data to validate the models and simulation methods 

Work with the force field development team to provide accurate and comprehensive reference molecular energies to enable force field development

Collaborate with platform teams to deploy the above models and simulation methods in target evaluation and drug discovery projects to enable or substantially accelerate such efforts

Work with experimental groups to validate and benchmark the computational models in drug discovery projects, and communicate the benchmark results and project impact across the company

Work with scientific leadership at Silicon Tx to develop the strategy for company success through accurate simulations

Recruit top talents, mentor the team, develop individual skills, demonstrate leadership, and support an inclusive culture of scientific innovation

Required Qualifications: 

• Highly motivated to develop computational methods for discovering better medicines

• M.S. or Ph.D. in computational physics/chemistry, physical chemistry/chemical physics, applied mathematics, or related fields

• Extensive past experience in quantum chemistry, force field development, and molecular dynamics simulations

• Extensive programming experience (C/C++ and Python preferred)

• Excellent communication skills and strong team player

Additional Desirable Qualifications: 

• Experience working with a diverse team on an ambitious project

• Experience in deep learning and numerical optimization 

 

Silicon Therapeutics provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.

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