Posted: Sep. 15, 2020
Silicon Therapeutics (“SITX”) is a privately held, physics-driven integrated drug discovery company in the preclinical IND stage targeting innate immunity to start, but with the capability to move into many other franchise opportunities. The Company’s initial pipeline is focused on modulation of the innate immune system to “light the spark” within immunologically cold tumors by using its physics-enabled drug discovery engine for the design of small molecule therapeutics and the lead program is in late stage preclinical studies. SITX’s discovery efforts as well as physics-based platform are all completely in-house, with a full wet lab as well as a team of over 25 experienced R&D professionals spanning biology, biochemistry, chemistry, biophysics (NMR + X-ray) & preclinical sciences. SITX’s engine leverages quantum mechanics and molecular dynamics, which are deployed on its own internal supercomputer composed of over 400 GPU’s and FPGA’s and allows SITX to accurately simulate the physical motion and properties of biological targets at an atomistic level resolution. The platform is completely proprietary to SITX and was built from the ground up with the purpose of addressing difficult targets and using simulations to break through bottlenecks that has plagued traditional drug discovery approaches on such targets. It is currently the ONLY company which owns the entire spectrum of physics-driven drug discovery from chip-to-clinic with a team of over 50 individuals in Boston.
The Company’s initial focus is on innate immunity and its pipeline is currently composed of one project entering IND-enabling studies, another one entering hit-to-lead and two more ramping up. It’s unique advantage in designing small molecules using all atom simulations has allowed it to advance a systemically available small molecule STING agonist into a preclinical development. The program is ramping up for IND enabling studies entry to the clinic in 2020. This differentiated product can be administered systemically via an IV dose and has single agent effects in early mouse efficacy studies using PD1 resistant tumor models and is a “rule-of-5” compliant small molecule. Beyond this one program, the Company is also advancing an ADAR inhibitor which can be considered an innate immune checkpoint as well as a multitude of targets that explore Innate Immunity’s role in cancer biology.
We are seeking an Associate Director/ Director of Alliance Management. This newly created position will report to the Chief Business Officer. S/he is responsible for ensuring that strategic partnerships are proactively and effectively launched and managed.
• Manage strategic partnerships in research, development and commercialization.
• Oversee the governance of strategic partnerships including managing governance committees, identifying key issues and solution-driving.
• Ensure that program activities are well-coordinated, that there is effective communication between parties and that potential issues are proactively surfaced to ensure that objectives of the alliance are met.
• Compliance/contract management – liaise with legal, finance, R&D and other functions to ensure that key contract milestones, financial transactions, progress reports, etc. are handled appropriately and provide information/updates as needed.
• Drive process, with legal function, to amend contracts or execute ancillary agreements to clarify or address specific needs or processes within collaborations.
• Create an environment of continuous improvement: conduct periodic collaboration health checks with stakeholders and implement feedback to optimize alliance value.
• The candidate will also work a portion of their time on business development-related activities including coordination in due diligence processes.
• Life sciences degree, PhD degree preferred.
• 3-7 years of experience in managing research and/or clinical-stage alliances within an Alliance Management/Business Development function in biotech or pharma.
• Solid understanding of discovery research, process development, technology transfer, clinical development, and regulatory processes in the biopharmaceutical industry
• Experience in the application of program management principles, tools and practices
• Comfortable interpreting and managing to collaboration contracts.
• Strong problem-solving and analytical skills and excellent business judgment.
• Excellent leadership and communication skills, with proven ability to influence across management levels, functions, and organizations.
• Demonstrated strong interpersonal, teamwork, analytical, organizational and negotiation skills.
Silicon Therapeutics provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.Apply